Serotonin Reuptake Inhibitor (SSRI) - Used in the treatment of separation anxiety in dogs, obsessive disorders, and phobias. trade name Reconcile.

• A. Sertraline
• B. Paroxetine
• C. Citalopram
• D. Fluoxetine

Answer: (D)

Fluoxetine is the SSRI specifically marketed for dogs under the trade name Reconcile, and it’s indicated for behavioral issues like separation anxiety, obsessive-compulsive–like disorders, and phobias. The way SSRIs work is by blocking the reuptake of serotonin, increasing its availability in the brain to help modulate anxiety and compulsive behaviors. Among the options, fluoxetine is the one formulated and approved for veterinary use under the Reconcile brand, making it the best match for the description. The other antidepressants listed are SSRIs used in people and sometimes used off-label in animals, but they are not the veterinary product associated with Reconcile. In practice, you start with a low dose and titrate over several weeks to see behavioral improvement, while monitoring for side effects such as reduced appetite, GI upset, or sedation, and being mindful of potential drug interactions that can affect bleeding risk when combined with NSAIDs.