Tricyclic antidepressant, a serotonin re-uptake blocker, used to treat separation anxiety,obsessive disorders, and aggression in dogs, spraying in cats. trade name Clomicalm

• A. Amitriptyline
• B. Clomipramine
• C. Fluoxetine
• D. Sertraline

Answer: (B)

Clomipramine is a tricyclic antidepressant that strongly inhibits the serotonin transporter, increasing serotonin in brain pathways involved in anxiety and compulsive behaviors. This makes it effective for canine separation anxiety, obsessive-compulsive–like disorders, and aggression, and it’s marketed in veterinary medicine as Clomicalm for these indications (including spraying in cats). Among the options, this drug uniquely fits both the pharmacologic profile (a TCA with potent serotonin reuptake inhibition) and the specific veterinary uses described. The other options are either different classes (SSRIs) or TCAs not specifically associated with the Clomicalm indication set.